No, Tempurpedic mattresses cannot be flipped because of their one-sided design.
Each mattress has three layers arranged from top to bottom. These include a base layer, a support layer, and a comfort layer.

The base layer is designed to conform to your body, dissipate heat, and reduce pressure buildup. If you flip your mattress, you’ll miss out on these benefits.
A better way to extend the lifespan of a Tempurpedic mattress is by simply rotating it. Rotating the mattress should be done every 6 to 12 months for optimal performance.